山東誠(chéng)匯醫(yī)藥集團(tuán)有限公司成立于2002年6月，注冊(cè)資本1.3億元，總部位于四面荷花三面柳,一城山色半城湖的歷史文化名城-山東濟(jì)南。是一家專注于醫(yī)藥原料藥、中間體、精細(xì)化工產(chǎn)品研發(fā)、生產(chǎn)、銷售及服務(wù)一體的高新技術(shù)企業(yè)，并致力于MAH、CDMO、獸藥、農(nóng)化等領(lǐng)域的新技術(shù)研發(fā)及應(yīng)用。集團(tuán)現(xiàn)擁有1個(gè)研發(fā)中心-山東誠(chéng)創(chuàng)藍(lán)海醫(yī)藥科技有限公司，1個(gè)原料藥廠-山東誠(chéng)匯雙達(dá)藥業(yè)有限公司及兩個(gè)醫(yī)藥中間體生產(chǎn)基地，現(xiàn)有職工1000余人，研發(fā)團(tuán)隊(duì)300余人。

產(chǎn)品概況

GMP

鹽酸利多卡因、利多卡因、鹽酸丁卡因、丙胺卡因、塞來(lái)昔布、舒更葡糖鈉、奧扎格雷鈉、拉西地平、鹽酸烏拉地爾

I狀態(tài)

富馬酸伏諾拉生、克立硼羅 、鹽酸羅哌卡因、丁卡因、鹽酸布比卡因、鹽酸阿替卡因

上報(bào)CEP

米屈肼（已獲批）、鹽酸羅哌卡因（在審評(píng)）、鹽酸阿替卡因（在審評(píng)）

US-DMF

鹽酸丙胺卡因、丁卡因、鹽酸普莫卡因、富馬酸伏諾拉生

在研

來(lái)特莫韋、蘆可替尼、非奈利酮、瑪巴洛沙韋、阿帕他胺、他達(dá)拉非、氟雷拉納、阿福拉納、沙羅拉納等

*All our products are not offered in countries where valid patents exist. All responsibility with repect to third parties patent rights in specific countries lies exclusively with the buyers.

產(chǎn)品明細(xì)

Product Name	產(chǎn)品名稱	CAS
*Vonoprazan Fumarate	富馬酸伏諾拉生	1260141-27-2 881681-01-2
*Letermovir	來(lái)特莫韋	917389-32-3
*Dapagliflozin propanediol monohydrate	達(dá)格列凈一水丙二醇	960404-48-2
*Crisaborole	克立硼羅	906673-24-3
Prilocaine	丙胺卡因	721-50-6
Lidocaine hydrochloride	鹽酸利多卡因	6108-05-0
Lidocaine	利多卡因	137-58-6
Ozagrel sodium	奧扎格雷鈉	189224-26-8
Celecoxib	塞來(lái)昔布	169590-42-5
Ropivacaine hydrochloride	鹽酸羅哌卡因	132112-35-7
Sugammadex  sodium	舒更葡糖鈉	343306-79-6
Tetracaine hydrochloride	鹽酸丁卡因	136-47-0
Tetracaine	丁卡因	94-24-6
Prilocaine hydrochloride	鹽酸丙胺卡因	1786-81-8
Pramoxine hydrochloride	鹽酸普莫卡因	637-58-1
Meldonium	米屈肼	86426-17-7
Bupivacaine hydrochloride	鹽酸布比卡因	73360-54-0
Bupivacaine	布比卡因	2180-92-9
Articaine hydrochloride	鹽酸阿替卡因	23964-57-0
Tadalafil	他達(dá)那非	171596-29-5
*Apalutamide	阿帕他胺	956104-40-8
*Baloxavir Marboxil	瑪巴洛沙韋	1985606-14-1
*Fluralaner	氟雷拉納	864731-61-3
*Afoxolaner	阿福拉納	1093861-60-9
*Sarolaner	沙羅拉納	1398609-39-6
*Ruxolitinib	蘆可替尼	941678-49-5
*Finerenone	非奈利酮	1050477-31-0
*Upadacitinib	烏帕替尼	1310726-60-3
Ozenoxacin	奧澤沙星	245765-41-7
Donepezil hydrochloride	鹽酸多奈哌齊	120011-70-3
Levobupivacaine hydrochloride	鹽酸左布比卡因	27262-48-2
Dibucaine hydrochloride	鹽酸地布卡因	CAS：61-12-1
Mepivacaine hydrochloride	鹽酸甲哌卡因	1722-62-9
Medetomidine hydrochloride	鹽酸美托咪啶	86347-15-1
Dyclonine hydrochloride	鹽酸達(dá)克羅寧	536-43-6
Dienogest	地諾孕素	65928-58-7
Altrenogest	烯丙孕素/四烯雌酮	850-52-2
Brexanolone	5alpha-孕甾-3alpha-醇-20-酮	516-54-1
Metoclopramide	甲氧氯普胺（胃復(fù)安）	364-62-5
Brinzolamide	布林佐胺	138890-62-7
Terbinafine hydrochloride	鹽酸特比萘芬	78628-80-5
Mexidole	美昔得樂(lè)	127464-43-1
Dexmedetomidine hydrochloride	鹽酸右美托咪定	145108-58-3
Nadifloxacin	那氟沙星	124858-35-1
富馬酸伏諾拉生中間體 Vonoprazan Fumarate Intermediates
5-(2-fluorophenyl)-1H-Pyrrole-3-carboxaldehyde	5-(2-氟苯基)-1H-吡咯-3-甲醛	881674-56-2
Pyridine-3-sulfonyl chloride hydrochloride	吡啶-3-磺酰氯	16133-25-8
達(dá)格列凈中間體 Dapagliflozin Intermediates
5-bromo-2-chloro-4’-ethoxydiphenylmethane	5-溴-2-氯-4’-乙氧基二苯甲烷	461432-23-5
[(2R,3R,4R,5S,6S)-3,4,5-triacetyloxy-6-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]oxan-2-yl]methyl acetate	(2R,3R,4R,5S,6S)-2-(乙酰氧基甲基)-6-(4-氯-3-(4-乙氧基芐基)苯基)四氫-2H-吡喃-3,4,5-三yl 三乙酸酯	461432-25-7
來(lái)特莫韋中間體 Letemovir Intermediates
2-(8-fluoro-3-(2-methoxy-5-(trifluoromethyl)phenyl) -2-oxo-1,2,3,4-tetrahydroquinazolin-4-yl) acetic acid methyl ester	2-(8-氟-3-(2-甲氧基-5-(三氟甲基)苯基)-2-氧代-1,2,3,4-四氫喹唑啉-4-基)乙酸甲酯	917389-21-0
1-(3-Methoxyphenyl)Piperazine Hydrochloride	1-(3-甲氧基苯基)哌嗪鹽酸鹽	16015-70-6
克立硼羅中間體 Crisaborole Intermediates
2-bromo-5-hydroxybenzaldehyde	2-溴-5-羥基苯甲醛	2973-80-0
4-[4-bromo-3-(hydroxymethyl)phenoxy]benzonitrile	4-[4-溴-3-(羥基甲基)苯氧基]苯甲腈	906673-45-8
[2-bromo-5-(4-cyanophenoxy)phenyl]methyl acetate	2-溴-5-（4-氰基苯氧基）乙酸芐酯	2227126-09-0
瑪巴洛沙韋中間體 Baloxavir Marboxil Intermediates
(R)-7-(benzyloxy)- 3,4,12,12a-tetrahydro- 1H-[1,4]oxazino[3,4- c]pyrido[2,1-f][1,2,4]- triazine-6,8-dione	(R)-7-(芐氧基)-3,4,12,12A-四氫-1H-[1,4]噁嗪[3,4-C]吡啶并[2,1-F] [1,2,4]三嗪-6,8二酮（巴沙洛韋母核）	1985607-70-2
3-(Benzyloxy)-4-oxo-4h-pyran-2-carboxylic acid	3-(芐氧基)-4-氧代-4H-吡喃-2-羧酸	119736-16-2
7,8-difluoro-6,11-dihydro-Dibenzo[b,e]thiepin-11-ol	7,8 -二氟- 6,11 -二氫-二苯并[ B,E ]噻吩并- 11 -醇	1985607-83-7
非奈利酮中間體 Finerenone Intermediates
4-formyl-3-methoxybenzonitrile	4-氰基-2-甲氧基苯甲醛	21962-45-8
4-amino-5-methylpyridone	4-氨基-5-甲基-2-羥基吡啶	95306-64-2
2-cyanoethylacetoacetate	2-氰基乙酰乙酸乙酯	65193-87-5
2-chloro-5-methylpyridin-4-amine	2-氯-4-氨基-5-甲基吡啶	79055-62-2
阿帕他胺中間體 Apalutamide Intermediates
5-Amino-3-(trifluoromethyl)picolinonitrile	5-氨基-3-(三氟甲基)氰基吡啶	573762-62-6
N-Boc-1-aminocyclobutanecarboxylic acid	Boc-1-氨基環(huán)丁烷羧酸	120728-10-1
1-amino-N-[6-cyano-5-(trifluoromethyl)-3-pyridinyl]Cyclobutanecarboxamide	1-氨基-N-[6-氰基-5-(三氟甲基)-3-吡啶基]-環(huán)丁烷甲酰胺	1950587-17-3
磷酸蘆可替尼中間體 Ruxolitinib Phosphate Intermediates
1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole	1-(1-乙氧基乙基)-4-吡唑硼酸頻哪醇酯	1029716-44-6
3-Cyclopentylacrylonitrile	3-環(huán)戊基丙烯腈	591769-05-0
(4-(1-(2-Cyano-1-cyclopentylethyl)-1h-pyrazol-4-yl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate	(4-(1-(2-氰基-1-環(huán)戊基乙基)-1h-吡唑-4-基)-7h-吡咯并[2,3-d]嘧啶-7-基)特戊酸甲酯	1236033-05-8
烏帕替尼中間體 Upadacitinib Intermediates
(3R,4S)-3-(2-Bromoacetyl)-4-ethyl-1-pyrrolidinecarboxylic acid phenylmethyl ester	(3R,4S)-3-(2-溴乙?；?-4-乙基-1-吡咯烷羧酸芐酯	1428243-26-8
tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate	5-甲苯磺?；?5H-吡咯并[2,3-B]吡嗪-2-胺基甲酸叔丁酯	1201187-44-1
8-((3R,4S)-4-ethylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine	8-((3S,4R)-4-乙基吡咯烷-3-基)-3-甲苯磺?；?3H-咪唑并[1,2-a]吡咯并[2,3-e]吡嗪	1428243-28-0
奧澤沙星中間體 Ozenoxacin Intermediates
ethyl 7-chloro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate	奧澤沙星中間體A	103877-51-6
5-broMo-N,3-diMethylpyridin-2-aMine	奧澤沙星中間體B	245765-66-6
[6-[benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid	奧澤沙星中間體D	446299-81-6
布林佐胺中間體 Brinzolamide Intermediates
(S)-3,4-dihydro-6-chloro-4-hydroxy-2H-thieno[3,2-e]-1,2-thiazine-1,1-dioxide	(S)-6-氯-3,4-二氫-2H-噻吩并[3,2-e]-1,2-噻嗪-4-醇1,1-二氧化物	160982-16-1
(S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide	(S)-3,4-二氫-4-羥基-2-(3-甲氧基丙基)-2H-噻吩并[3,2-e]-1,2-噻嗪-6-磺胺-1,1-二氧化物	154127-42-1
鹽酸阿替卡因中間體 Articaine hydrochloride Intermediates
3-Amino-4-methyl-2-thiophene carboxylic acid methyl ester	3-氨基-4-甲基噻吩-2-甲酸甲酯	85006-31-1
鹽酸羅哌卡因中間體 Ropivacaine Intermediates
N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide	N-(2,6-二甲苯基)-2-哌啶甲酰胺	15883-20-2
(2S)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide	(S)-N-(2,6-二甲苯基)-2-哌啶甲酰胺	27262-40-4
別孕酮中間體 Brexanolone Intermediates
Allopregnan-3β-ol-20-one acetate	別孕烯醇酮醋酸酯	906-83-2
3β-hydroxy-5α-pregnan-20-one	別孕烯醇酮	516-55-2
氟雷拉納中間體 Fluralaner Intermediates
4-acetyl-2-methylbenzoic acid	2-甲基-4-乙?；郊姿?/span>	55860-35-0
2-AMino-N-(2,2,2-trifluoroethyl)acetaMide hydrochloride	2-氨基-N-(2,2,2-三氟乙基)乙酰胺鹽酸鹽	1171331-39-7
3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE	3', 5'-二氯-2, 2, 2-三氟苯乙酮	130336-16-2
阿福拉納中間體 Afoxolaner Intermediates
4-acetyl-1-naphthoic acid	4-乙?；良姿?/span>	131986-05-5
2-AMino-N-(2,2,2-trifluoroethyl)acetaMide hydrochloride	2-氨基-N-(2,2,2-三氟乙基)乙酰胺鹽酸鹽	1171331-39-7
1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone	1-[3-氯-5-(三氟甲基)苯基]-2,2,2-三氟乙酮	1125812-58-9

*All our products are not offered in countries where valid patents exist. All responsibility with repect to third parties patent rights in specific countries lies exclusively with the buyers.

MAH業(yè)務(wù)

從現(xiàn)有原料藥基礎(chǔ)上進(jìn)行制劑項(xiàng)目深度挖掘，形成細(xì)分領(lǐng)域?qū)I(yè)化MAH路線，已開展11項(xiàng)MAH項(xiàng)目，其中舒更葡糖鈉項(xiàng)目已獲批，利丁卡因制劑已上報(bào)至國(guó)家局進(jìn)入臨床研究階段。

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